Structure of PDB 5ze4 Chain A Binding Site BS02

Receptor Information
>5ze4 Chain A (length=569) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSVTADPSPPTNKLNKYSSRITEPKSQGGSQAILHGVGLSDDDLLKPQIG
ISSVWYEGNTCNMHLLKLSEAVKEGVENAGMVGFRFNTIGVSDAISMGTR
GMCFSLQSRDLIADSIETVMSAQWYDGNISIPGCDKNMPGTIMAMGRLNR
PGIMVYGGTIKPGHFQDKTYDIVSAFQSYGEFVSGSISDEQRKTVLHHSC
PGAGACGGMYTANTMASAIEAMGMSLPYSSSIPAEDPLKLDECRLAGKYL
LELLKMDLKPRDIITPKSLRNAMVSVMALGGSTNAVLHLIAIARSVGLEL
TLDDFQKVSDAVPFLADLKPSGKYVMEDIHKIGGTPAVLRYLLELGLMDG
DCMTVTGQTLAQNLENVPSLTEGQEIIRPLSNPIKETGHIQILRGDLAPD
GSVAKITGKEGLYFSGPALVFEGEESMLAAISADPMSFKGTVVVIRGEGP
KGGPGMPEMLTPTSAIMGAGLGKECALLTDGRFSGGSHGFVVGHICPEAQ
EGGPIGLIKNGDIITIDIGAARIDTQVSPEEMNDRRKKWTAPAYKVNRGV
LYKYIKNVQSASDGCVTDE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5ze4 Chain A Residue 606 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ze4 Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action.
Resolution2.11 Å
Binding residue
(original residue number in PDB)		D98 D140 E463
Binding residue
(residue number reindexed from 1)		D93 D135 E458
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.1.9: dihydroxy-acid dehydratase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004160 dihydroxy-acid dehydratase activity
GO:0005507 copper ion binding
GO:0016829 lyase activity
GO:0016836 hydro-lyase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009082 branched-chain amino acid biosynthetic process
GO:0009097 isoleucine biosynthetic process
GO:0009099 L-valine biosynthetic process
GO:0009553 embryo sac development
GO:0009555 pollen development
GO:0009651 response to salt stress
GO:0048364 root development
Cellular Component
GO:0005829 cytosol
GO:0009507 chloroplast
GO:0009536 plastid
GO:0009570 chloroplast stroma

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ze4, PDBe:5ze4, PDBj:5ze4
PDBsum5ze4
PubMed29995859
UniProtQ9LIR4|ILVD_ARATH Dihydroxy-acid dehydratase, chloroplastic (Gene Name=DHAD)

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