Structure of PDB 5ze3 Chain A Binding Site BS02

Receptor Information

>5ze3 Chain A (length=441) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EQPLVRLRGGAYIGEGRVEVLKNGEWGTVCDDKWDLVSASVVCRELGFGS
AKEAVTGSRLGQGIGPIHLNEIQCTGNEKSIIDCKFNAESQGCNHEEDAG
VRCNTPAMGLQKKLRLNGGRNPYEGRVEVLVERQGSLVWGMVCGQNWGIV
EAMVVCRQLGLGFASNAFQETWYWHGDVNSNKVVMSGVKCSGTELSLAHC
RHDGEDVACPQGGVQYGAGVACSETAPDLVLNAEMVQQTTYLEDRPMFLL
QCAMEENCLSASAAQTDPTTGYRRLLRFSSQIHNNGQSDFRPKNGRHAWI
WHDCHRHYHSMEVFTHYDLLNLNGTKVAEGHKASFCLEDTECEGDIQKNY
ECANFGDQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVA
ESDYSNNIMKCRSRYDGHRIWMYNCHIGGSFSEETEKKFEH

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5ze3 Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5ze3 Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	H626 H628 H630 Y689
Binding residue (residue number reindexed from 1)	H305 H307 H309 Y368
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.4.3.13: protein-lysine 6-oxidase.

Gene Ontology

	Molecular Function
GO:0005507	copper ion binding
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

	Cellular Component
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5ze3, PDBe:5ze3, PDBj:5ze3
PDBsum	5ze3
PubMed	29581294
UniProt	Q9Y4K0\|LOXL2_HUMAN Lysyl oxidase homolog 2 (Gene Name=LOXL2)

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