Structure of PDB 5ze2 Chain A Binding Site BS02

Receptor Information
>5ze2 Chain A (length=618) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPRQHLLSLTRRAQKHRLRELKIQVKEFADKEEGGDVKAVCLTLFLLALR
ARNEHRQADELEAIMQGRGSGLQPAVCLAIRVNTFLSCSQYHKMYRTVKA
ITGRQIFQPLHALRNAEKVLLPGYHPFEWQPPLKNVSSRTDVGIIDGLSG
LASSVDEYPVDTIAKRFRYDSALVSALMDMEEDILEGMRSQDLDDYLNGP
FTVVVKESCDGMGDVSEKHGSGPAVPEKAVRFSFTVMRITIEHGSQNVKV
FEEPKPNSELCCKPLCLMLADESDHETLTAILSPLIAEREAMKSSELTLE
MGGIPRTFKFIFRGTGYDEKLVREVEGLEASGSVYICTLCDTTRLEASQN
LVFHSITRSHAENLQRYEVWRSNPYHESVEELRDRVKGVSAKPFIETVPS
IDALHCDIGNAAEFYKIFQLEIGEVYKHPNASKEERKRWQATLDKHLRKR
MNLKPIMRMNGNFARKLMTQETVDAVCELIPSEERHEALRELMDLYLKMK
PVWRSSCPAKECPESLCQYSFNSQRFAELLSTKFKYRYEGKITNYFHKTL
AHVPEIIERDGSIGAWASEGNESGNKLFRRFRKMNARQSKCYEMEDVLKH
HWLYTSKYLQKFMNAHNA
Ligand information
>5ze2 Chain G (length=40) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggtttttgtctggcttcacacttgatttgcatcactgtg
Receptor-Ligand Complex Structure
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PDB5ze2 Cracking the DNA Code for V(D)J Recombination
Resolution3.3 Å
Binding residue
(original residue number in PDB)		R391 R393 Q394 L399 T400 R402 A403 R407 Y485 K489 Q495 H501 K608 H609 G610 Q978
Binding residue
(residue number reindexed from 1)		R1 R3 Q4 L9 T10 R12 A13 R17 Y95 K99 Q105 H111 K218 H219 G220 Q588
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0043565 sequence-specific DNA binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0033151 V(D)J recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:5ze2, PDBe:5ze2, PDBj:5ze2
PDBsum5ze2
PubMed29628308
UniProtP15919|RAG1_MOUSE V(D)J recombination-activating protein 1 (Gene Name=Rag1)

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