Structure of PDB 5yzx Chain A Binding Site BS02

Receptor Information
>5yzx Chain A (length=484) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IDFNDELRNRREKLAALRQQGVAFPNDFRRDHTSDQLHEEFDAKDNQELE
SLNIEVSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDSLPEGVYNDQ
FKKWDLGDIIGARGTLFKTQTGELSIHCTELRLLDKALRPLPDQEVRYRQ
RYLDLIANDKSRQTFVVRSKILAAIRQFMVARGFMEVETPMMQVIPGGAS
ARPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISV
RHNPEFTMMELYMAYADYHDLIELTESLFRTLAQEVLGTTKVTYGEHVFD
FGKPFEKLTMREAIKKYRPETDMADLDNFDAAKALAESIGITVEKSWGLG
RIVTEIFDEVAEAHLIQPTFITEYPAEVSPLARRNDVNPEITDRFEFFIG
GREIGNGFSELNDAEDQAERFQEQVNAKAAGDDEAMFYDEDYVTALEYGL
PPTAGLGIGIDRMIMLFTNSHTIRDVILFPAMRP
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5yzx Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5yzx A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E414 E421 N424
Binding residue
(residue number reindexed from 1)		E396 E403 N406
Annotation score1
Enzymatic activity
Enzyme Commision number 6.1.1.6: lysine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004824 lysine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006430 lysyl-tRNA aminoacylation
GO:0034605 cellular response to heat
GO:0036260 RNA capping
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5yzx, PDBe:5yzx, PDBj:5yzx
PDBsum5yzx
PubMed
UniProtP0A8N5|SYK2_ECOLI Lysine--tRNA ligase, heat inducible (Gene Name=lysU)

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