Structure of PDB 5yum Chain A Binding Site BS02

Receptor Information

>5yum Chain A (length=91) Species: 83333 (Escherichia coli K-12)

HDNVILELTVRNHPGVMTHVCGLFARRAFNVEGILCLPIQDSDKSHIWLL
VNDDQRLEQMISQIDKLEDVVKVQRNQSDPTMFNKIAVFFQ

Ligand information

• Ligand ID: CO
• InChI: InChI=1S/Co/q+2
• InChIKey: XLJKHNWPARRRJB-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Co+2]
  CACTVS 3.341: [Co++]
• Formula: Co
• Name: COBALT (II) ION
• DrugBank: DB14205
• PDB chain: 5yum Chain A Residue 102

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5yum Crystallographic Structures of IlvN·Val/Ile Complexes: Conformational Selectivity for Feedback Inhibition of Aceto Hydroxy Acid Synthases.
• Resolution: 2.432 Å
• Binding residue (original residue number in PDB): H20 D76
• Binding residue (residue number reindexed from 1): H13 D69
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.2.1.6: acetolactate synthase.

Gene Ontology

Molecular Function

• GO:0003984 acetolactate synthase activity
• GO:0005515 protein binding
• GO:0016740 transferase activity
• GO:1990610 acetolactate synthase regulator activity

Biological Process

• GO:0008652 amino acid biosynthetic process
• GO:0009082 branched-chain amino acid biosynthetic process
• GO:0009097 isoleucine biosynthetic process
• GO:0009099 L-valine biosynthetic process

Cellular Component

• GO:0005829 cytosol
• GO:0005948 acetolactate synthase complex

External links

• PDB: RCSB:5yum, PDBe:5yum, PDBj:5yum
• PDBsum: 5yum
• PubMed: 30887800
• UniProt: P0ADF8|ILVN_ECOLI Acetolactate synthase isozyme 1 small subunit (Gene Name=ilvN)