Structure of PDB 5yth Chain A Binding Site BS02

Receptor Information
>5yth Chain A (length=539) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALR
DLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARR
YGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAH
MEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERV
LFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKS
TYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQR
IRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETA
SWMFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPYEEAQAFI
ERYFQSFPKVRAWIEKTLEEGRRRGYVETLFGRRRYVPDLEARVKSVREA
AERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPK
ERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yth Unnatural Cytosine Bases Recognized as Thymines by DNA Polymerases by the Formation of the Watson-Crick Geometry.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 S513 S515 A517 S543 T544 T569 A570 S575 S576 S577 D578 N580 G668 Y671 M673 S674 H676 R677 Q680 E681 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N190 N192 S193 S220 S222 A224 S250 T251 T276 A277 S282 S283 S284 D285 N287 G375 Y378 M380 S381 H383 R384 Q387 E388 R435 R453 M454 N457 Q461
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5yth, PDBe:5yth, PDBj:5yth
PDBsum5yth
PubMed30407705
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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