Structure of PDB 5yew Chain A Binding Site BS02

Receptor Information
>5yew Chain A (length=390) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDL
VEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSG
IGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKVNNQLAHALHMDKDLKA
GCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVL
VANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRR
QHMERCLHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAALAEGFHA
RLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAA
EDLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLP
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain5yew Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5yew Structural basis for GTP hydrolysis and conformational change of MFN1 in mediating membrane fusion
Resolution3.2 Å
Binding residue
(original residue number in PDB)		T84 H107 I108 T109 G181
Binding residue
(residue number reindexed from 1)		T80 H103 I104 T105 G177
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0008053 mitochondrial fusion
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:5yew, PDBe:5yew, PDBj:5yew
PDBsum5yew
PubMed29483649
UniProtQ8IWA4|MFN1_HUMAN Mitofusin-1 (Gene Name=MFN1)

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