Structure of PDB 5ybt Chain A Binding Site BS02

Receptor Information
>5ybt Chain A (length=293) Species: 104259 (Penicillium brasilianum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVPGSHMPPRLQRFPATASADEIFAAFQEDGCVVIEGFISPEQVARFSQE
VDPAMEKIPVEVTNSNDRTKRFSKCVIASPTFRNEIIESDLMHELCDRVF
SKPGEGMGYHFNDNMVIEVQPGAPAQRLHRDQELYPWWNSMGPAGPECLI
NFFCAVTPFTEENGATRLVPGSHLWPEFTQINERDCPQFGKIETVPAIMQ
PGDCYLMSGKVIHGAGHNATTTDRRRALALSIIRRELRPVQAFSLSVPMK
LAREMSERSQTMFGFRSSVQHCVDMVHFWGNDGKDIAHHLGLI
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain5ybt Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ybt Structure function and engineering of multifunctional non-heme iron dependent oxygenases in fungal meroterpenoid biosynthesis.
Resolution2.35 Å
Binding residue
(original residue number in PDB)
Q127 H130 F154 T167 H214 A216 R226
Binding residue
(residue number reindexed from 1)
Q126 H129 F153 T166 H213 A215 R225
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.-
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0016114 terpenoid biosynthetic process
GO:0140874 paraherquonin biosynthetic process

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Molecular Function

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Biological Process
External links
PDB RCSB:5ybt, PDBe:5ybt, PDBj:5ybt
PDBsum5ybt
PubMed29317628
UniProtA0A1E1FFL0|PRHA_PENBI Multifunctional dioxygenase prhA (Gene Name=prhA)

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