Structure of PDB 5y7g Chain A Binding Site BS02

Receptor Information
>5y7g Chain A (length=542) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALLV
RMVMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFGL
LKKDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPVY
ELRCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFRL
RADVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLFQ
FAQHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALAREA
SCAPESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSEP
CSVEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHPF
HSAPADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSPF
VYWELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWPA
QRRYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYVRWH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5y7g Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		K78 K116 K117 R134 K135 L192 K271 R293 R296 R300 R329 R333 E468
Binding residue
(residue number reindexed from 1)		K64 K102 K103 R120 K121 L178 K257 R279 R282 R286 R315 R319 E454
Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5y7g, PDBe:5y7g, PDBj:5y7g
PDBsum5y7g
PubMed29514982
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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