Structure of PDB 5y6z Chain A Binding Site BS02

Receptor Information
>5y6z Chain A (length=457) Species: 31704 (Coxsackievirus A16) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEIQWMKSNKETGRLNINGPTRTKLEPSAFYDVFEGSKKPAVLTSKDPRL
EVDFEQALFSKYVGNTLHEPDEYVTQAALHYANQLKQLDINVNKMSMEEA
CYGTEYLEAIDLHTSAGYPYSALGVKKRDILDPITRDTTKMKFYMDKYGL
DLPYSTYVKDELRSLDKIRKGKSRLIEASSLNDSVYLRMTFGHLYETFHA
NPGTVTGSAVGCNPDVFWSKLPILLPGSLFAFDYSGYDASLSPVWFRALE
VVLREIGYPEEAVSLIEGINHTHHVYRNRTYCVLGGMPSGCSGTSIFNSM
INNIIIRTLLIKTFKGIDLDELHMVAYGDDVLASYPFPIDCLELAKTGKE
YGLTMTPCFNEVTWENATFLKRGFLPDHQFPFLIHPTMPMREIHESIRWT
KDARNTQDHVRSLCLLAWHNGKEEYEKFVSTIRSVPIGRALAIPNYENLR
RNWLELF
Ligand information
Receptor-Ligand Complex Structure
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PDB5y6z Crystal structure of the coxsackievirus A16 RNA-dependent RNA polymerase elongation complex reveals novel features in motif A dynamics
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H113 S295 Y327 G328 L375 S401 N410 D413 H414 S417
Binding residue
(residue number reindexed from 1)		H113 S295 Y327 G328 L370 S396 N405 D408 H409 S412
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5y6z, PDBe:5y6z, PDBj:5y6z
PDBsum5y6z
PubMed29164396
UniProtL7WS61

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