Structure of PDB 5y4z Chain A Binding Site BS02

Receptor Information

>5y4z Chain A (length=440) Species: 64320 (Zika virus)

CFEPSMLKKKQLTVLDLHPGAGKTRRVLPEIVREAIKKRLRTVILAPTRV
VAAEMEEALRGLPVRYMTTAVNVTHSGTEIVDLMCHATFTSRLLQPIRVP
NYNLNIMDEAHFTDPSSIAARGYISTRVEMGEAAAIFMTATPPGTRDAFP
DSNSPIMDTEVEVPERAWSSGFDWVTDHSGKTVWFVPSVRNGNEIAACLT
KAGKRVIQLSRKTFETEFQKTKNQEWDFVITTDISEMGANFKADRVIDSR
RCLKPVILDGERVILAGPMPVTHASAAQRRGRIGRNPNKPGDEYMYGGGC
AETDEGHAHWLEARMLLDNIYLQDGLIASLYRPEADKVAAIEGEFKLRTE
QRKTFVELMKRGDLPVWLAYQVASAGITYTDRRWCFDGTTNNTIMEDSVP
AEVWTKYGEKRVLKPRWMDARVCSDHAALKSFKEFAAGKR

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5y4z Chain A Residue 702

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5y4z Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA
• Resolution: 1.3 Å
• Binding residue (original residue number in PDB): T201 E286
• Binding residue (residue number reindexed from 1): T24 E109
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0004386 helicase activity
• GO:0005524 ATP binding

External links

• PDB: RCSB:5y4z, PDBe:5y4z, PDBj:5y4z
• PDBsum: 5y4z
• UniProt: Q32ZE1|POLG_ZIKV Genome polyprotein