Structure of PDB 5y3r Chain A Binding Site BS02

Receptor Information
>5y3r Chain A (length=493) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDLL
AVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQD
MMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAKA
SRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISVHFEESSKLED
LLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRE
TNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFD
DPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLIKCLE
KEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFLPFAD
DKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHFRNLE
ALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDY
Ligand information
Receptor-Ligand Complex Structure
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PDB5y3r Cryo-EM structure of human DNA-PK holoenzyme
Resolution6.6 Å
Binding residue
(original residue number in PDB)		L256 S257 R258 K282 P284 P285 K331 R403 R404
Binding residue
(residue number reindexed from 1)		L215 S216 R217 K241 P243 P244 K290 R362 R363
Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5y3r, PDBe:5y3r, PDBj:5y3r
PDBsum5y3r
PubMed28840859
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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