Structure of PDB 5xzg Chain A Binding Site BS02
Receptor Information
>5xzg Chain A (length=357) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPL
SHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLI
RNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLV
PKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECL
KLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSC
FDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERN
NGFPIFD
Ligand information
>5xzg Chain F (length=14) [
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cgtcttcggcaatt
Receptor-Ligand Complex Structure
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PDB
5xzg
Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Resolution
1.828 Å
Binding residue
(original residue number in PDB)
S165 A168 N196 Y200 K372
Binding residue
(residue number reindexed from 1)
S17 A20 N48 Y52 K224
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:5xzg
,
PDBe:5xzg
,
PDBj:5xzg
PDBsum
5xzg
PubMed
28963528
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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