Structure of PDB 5xuu Chain A Binding Site BS02

Receptor Information
>5xuu Chain A (length=1213) Species: 1410628 (Lachnospiraceae bacterium ND2006) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSKLEKFTNCYSLSKTLRFKAIPVGKTQENIDNKRLLVEDEKRAEDYKGV
KKLLDRYYLSFINDVLHSIKLKNLNNYISLFRKKTRTEKENKELENLEIN
LRKEIAKAFKGNEGYKSLFKKDIIETILPEFLDDKDEIALVNSFNGFTTA
FTGFFDNRENMFSEEAKSTSIAFRCINENLTRYISNMDIFEKVDAIFDKH
EVQEIKEKILNSDYDVEDFFEGEFFNFVLTQEGIDVYNAIIGGFVTESGE
KIKGLNEYINLYNQKTKQKLPKFKPLYKQVLSDRESLSFYGEGYTSDEEV
LEVFRNTLNKNSEIFSSIKKLEKLFKNFDEYSSAGIFVKNGPAISTISKD
IFGEWNVIRDKWNAEYDDIHLVTEKYEDDRRKSFKKIGSFSLEQLQEYAD
ADLSVVEKLKEIIIQKVDEIYKVYGSSEKLFDADFVLEKSLKKNDAVVAI
MKDLLDSVKSFENYIKAFFGEGKETNRDESFYGDFVLAYDILLKVDHIYD
AIRNYVTQKPYSKDKFKLYFQNPQFMGGWDKDKETDYRATILRYGSKYYL
AIMDKKYAKCLQKIDKDDVNGNYEKINYKLLPGPNKMLPKVFFSKKWMAY
YNPSEDIQKIYKNGTFKKGDMFNLNDCHKLIDFFKDSISRYPKWSNAYDF
NFSETEKYKDIAGFYREVEEQGYKVSFESASKKEVDKLVEEGKLYMFQIY
NKDFSDKSHGTPNLHTMYFKLLFDENNHGQIRLSGGAELFMRRASLKKEE
LVVHPANSPIANKNPDNPKKTTTLSYDVYKDKRFSEDQYELHIPIAINKC
PKNIFKINTEVRVLLKHDDNPYVIGIDRGERNLLYIVVVDGKGNIVEQYS
LNEIINNFNGIRIKTDYHSLLDKKEKERFEARQNWTSIENIKELKAGYIS
QVVHKICELVEKYDAVIALEDLNSGFKNSRVKVEKQVYQKFEKMLIDKLN
YMVDKKSNPCATGGALKGYQITNKFESFKSMSTQNGFIFYIPAWLTSKID
PSTGFVNLLKTKYTSIADSKKFISSFDRIMYVPEEDLFEFALDYKNFSRT
DADYIKKWKLYSYGNRIRIFRDWEEVCLTSAYKELFNKYGINYQQGDIRA
LLCEQSDKAFYSSFMALMSLMLQMRNSITGRTDVDFLISPVKNSDGIFYD
SRNYEAQENAILPKNADANGAYNIARKVLWAIGQFKKAEDEKLDKVKIAI
SNKEWLEYAQTSV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xuu Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		D156 N160 K167 S168 G242 V245 K251 E257 N260 Q264 S286 S288 Y290 K349 W355 N509 T512 Q513 K514 D535 K538 Y542 K584 L585 S599 K600 Y646 K648 W649 S739 G740 N895 I896 K897 K945 S982 F983 K984
Binding residue
(residue number reindexed from 1)		D156 N160 K167 S168 G242 V245 K251 E257 N260 Q264 S286 S288 Y290 K349 W355 N504 T507 Q508 K509 D530 K533 Y537 K579 L580 S594 K595 Y641 K643 W644 S734 G735 N890 I891 K892 K940 S977 F978 K979
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5xuu, PDBe:5xuu, PDBj:5xuu
PDBsum5xuu
PubMed28781234
UniProtA0A182DWE3

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