Structure of PDB 5xq2 Chain A Binding Site BS02

Receptor Information
>5xq2 Chain A (length=679) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAVL
DLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE
LLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRKP
IPHLTGLLVPVLTLEDLHEEEGSLALSLPWEERRRRTREIASWIGRRLGL
GTPEAVRAQAYRLSIPKLMGVSKPADALRVGFYRAQETALALLRLDGAQG
WPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAV
LVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLA
KAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLP
EAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRNGRVPQDEFAL
ALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTV
HRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPL
HLADRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xq2 Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Resolution3.33 Å
Binding residue
(original residue number in PDB)		A47 R51 R114 E268 S328 K329 W415 H445 D478 G480 G481 E483 R486 G547 R548 R574 K575 S576 G577 D590 V606 F610 F647 F649 R668
Binding residue
(residue number reindexed from 1)		A44 R48 R111 E265 S322 K323 W409 H439 D472 G474 G475 E477 R480 G541 R542 R568 K569 S570 G571 D584 V600 F604 F641 F643 R662
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xq2, PDBe:5xq2, PDBj:5xq2
PDBsum5xq2
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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