Structure of PDB 5xpa Chain A Binding Site BS02

Receptor Information
>5xpa Chain A (length=679) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRK
PIPHLTGLLVPVLTLEDLHEELALSLPWEERRRRTREIASWIGRRLGLGT
PEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQ
GWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQA
VLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLL
AKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGDGGHLLWTLP
EAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRNGRVPQDEFAL
ALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTV
HRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPL
HLADRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xpa Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		E268 H271 K329 H445 R548 S576 D609 F647 K664
Binding residue
(residue number reindexed from 1)		E266 H269 K324 H440 R542 S570 D603 F641 K658
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xpa, PDBe:5xpa, PDBj:5xpa
PDBsum5xpa
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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