Structure of PDB 5xow Chain A Binding Site BS02

Receptor Information
>5xow Chain A (length=684) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVAR
RAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPK
DPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGA
VLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRT
WELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPR
KPIPHLTGLLVPVLTLEDLHEEEGSLALSLPWEERRRRTREIASWIGRRL
GLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRL
DGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEE
GVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENAL
LGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHL
LWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRNGRVPQ
DEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTF
LLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPR
LPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xow Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Resolution2.902 Å
Binding residue
(original residue number in PDB)		E268 P412 M413 H445 G547 R548 R574 K575 S576 R608 F647
Binding residue
(residue number reindexed from 1)		E267 P411 M412 H444 G546 R547 R573 K574 S575 R607 F646
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xow, PDBe:5xow, PDBj:5xow
PDBsum5xow
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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