Structure of PDB 5xou Chain A Binding Site BS02

Receptor Information
>5xou Chain A (length=564) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREVLGGAVLDLWVSDSG
AFLLEVDPALPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKL
MGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGA
SGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRL
KALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPA
ELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWD
LLEETLWAFRRKAGRLPSRVLLLRNGRVPQDEFALALEALAREGIAYDLV
SVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVH
EAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGI
RHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
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PDB5xou Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Resolution2.63 Å
Binding residue
(original residue number in PDB)		P44 A47 R114 S328 K329 H445 G481 G547 R574 K575 S576 D590 V606 H607 R608 F610 R640 F647 F649 K664 R668
Binding residue
(residue number reindexed from 1)		P41 A44 R111 S207 K208 H324 G360 G426 R453 K454 S455 D469 V485 H486 R487 F489 R519 F526 F528 K543 R547
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xou, PDBe:5xou, PDBj:5xou
PDBsum5xou
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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