Structure of PDB 5xog Chain A Binding Site BS02

Receptor Information
>5xog Chain A (length=1414) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG
GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK
VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD
APKVVSRGGCGNTQPVVRKDGMKLWGTWKKSRDAQPERKLLTPGEILNVF
KHISPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDD
LTHKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQ
PQALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLEL
DQVGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGD
RIDLRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVK
VMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQI
VSPQSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVP
QPAILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGK
VMFGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNG
FSIGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLR
ESFEGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQM
SACVGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQ
EFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLG
DIIQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPD
VIEYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNL
RRIIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEA
QQNATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHP
GEMVGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDRE
IALDIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAY
FSQSPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADK
LIIRCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESG
EYKNEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRS
SLYKEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGA
LMRCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMID
EKLLTSLPADYAPT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5xog Structure of the complete elongation complex of RNA polymerase II with basal factors
Resolution3.0 Å
Binding residue
(original residue number in PDB)		M253 A310 K333 R338 R345 R351 Q448 T832 A833 G836 Y837 R1389 E1406 E1407
Binding residue
(residue number reindexed from 1)		M241 A298 K321 R326 R333 R339 Q436 T820 A821 G824 Y825 R1340 E1357 E1358
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xog, PDBe:5xog, PDBj:5xog
PDBsum5xog
PubMed28775211
UniProtC4R4Y0

[Back to BioLiP]