Structure of PDB 5xjb Chain A Binding Site BS02

Receptor Information

>5xjb Chain A (length=341) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKE
IDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRF
TARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGQNASKGIYAMASRDVFL
LKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVG
LQEYLVTCADDVIKMINMGSACRTSGQSSRSHACFQILLRTKGRLHGKFS
LVDLAGNERGADRMEGAEINKSLLALKECIRALGQNKHTPFRESKLTQVL
RDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELS

Ligand information

Ligand ID

BEF

InChI

InChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3

InChIKey

OGIAHMCCNXDTIE-UHFFFAOYSA-K

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	[Be-](F)(F)F
ACDLabs 10.04 CACTVS 3.341	F[Be-](F)F

Formula

Be F3

Name

BERYLLIUM TRIFLUORIDE ION

ChEMBL

DrugBank

ZINC

PDB chain

5xjb Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5xjb Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation
Resolution	3.1 Å
Binding residue (original residue number in PDB)	K350 R452 S463 S464 S466 D488 L489
Binding residue (residue number reindexed from 1)	K127 R223 S228 S229 S231 D253 L254
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding

	Biological Process
GO:0007018	microtubule-based movement

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5xjb, PDBe:5xjb, PDBj:5xjb
PDBsum	5xjb
PubMed	28903043
UniProt	Q922S8\|KIF2C_MOUSE Kinesin-like protein KIF2C (Gene Name=Kif2c)

[Back to BioLiP]