Structure of PDB 5xh7 Chain A Binding Site BS02 |
| >5xh7 Chain A (length=1283) Species: 1111120 (Acidaminococcus sp. BV3L6)
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MTQFEGFTNLYQVSKTLRFELIPQGKTLKHIQEQGFIEEDKARNDHYKEL
KPIIDRIYKTYADQCLQLVQLDWENLSAAIDSYRKEKTEETRNALIEEQA
TYRNAIHDYFIGRTDNLTDAINKRHAEIYKGLFKAELFNGKVLKQLGTVT
TTEHENALLRSFDKFTTYFSGFYENRKNVFSAEDISTAIPHRIVQDNFPK
FKENCHIFTRLITAVPSLREHFENVKKAIGIFVSTSIEEVFSFPFYNQLL
TQTQIDLYNQLLGGISREAGTEKIKGLNEVLNLAIQKNDETAHIIASLPH
RFIPLFKQILSDRNTLSFILEEFKSDEEVIQSFCKYKTLLRNENVLETAE
ALFNELNSIDLTHIFISHKKLETISSALCDHWDTLRNALYERRISELTGK
ITKSAKEKVQRSLKHEDINLQEIISAAGKELSEAFKQKTSEILSHAHAAL
DQPLPTTLKKQEEKEILKSQLDSLLGLYHLLDWFAVDESNEVDPEFSARL
TGIKLEMEPSLSFYNKARNYATKKPYSVEKFKLNFQMPTLARGWDVNKEK
NNGAILFVKNGLYYLGIMPKQKGRYKALSFEPTEKTSEGFDKMYYDYFPD
AAKMIPRCSTQLKAVTAHFQTHTTPILLSNNFIEPLEITKEIYDLNNPEK
EPKKFQTAYAKKTGDQKGYREALCKWIDFTRDFLSKYTKTTSIDLSSLRP
SSQYKDLGEYYAELNPLLYHISFQRIAEKEIMDAVETGKLYLFQIYNKDF
AKGHHGKPNLHTLYWTGLFSPENLAKTSIKLNGQAELFYRPKSRMMAHRL
GEKMLNKKLKDQKTPIPDTLYQELYDYVNHRLSHDLSDEARALLPNVITK
EVSHEIIKDRRFTSDKFFFHVPITLNYQAANSPSKFNQRVNAYLKEHPET
PIIGIDRGERNLIYITVIDSTGKILEQRSLNTIQQFDYQKKLDNREKERV
AARQAWSVVGTIKDLKQGYLSQVIHEIVDLMIHYQAVVVLENLNFAVYQQ
FEKMLIDKLNCLVLKDYPAEKVGGVLNPYQLTDQFTSFAKMGTQSGFLFY
VPAPYTSKIDPLTGFVDPFVWKTIKNHESRKHFLEGFDFLHYDVKTGDFI
LHFKMNRNLSFQRGLPGFMPAWDIVFEKNETQFDAKGTPFIAGKRIVPYR
DLYPANELIALLEEKGIVFRDGSNILPKLLENDDSHAIDTMVALIRSVLQ
MRNSNAATGEDYINSPVRDLNGVCFDSRFQNPEWPMDADANGAYHIALKG
QLLLNHLKESKDLKLQNGISNQDWLAYIQELRN |
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| PDB | 5xh7 Structural Basis for the Altered PAM Recognition by Engineered CRISPR-Cpf1 |
| Resolution | 2.0 Å |
Binding residue
(original residue number in PDB) | K164 N178 I185 S186 G263 S266 K273 N278 E279 N282 R301 T315 S317 I319 S376 W382 N519 T522 K523 K524 R542 G543 D545 N547 K548 Y597 P599 K603 M604 L612 K613 N631 Y687 K689 K780 N782 G783 Q784 R951 R955 G962 T963 I964 K965 Q1013 Q1014 S1051 F1052 |
Binding residue
(residue number reindexed from 1) | K164 N178 I185 S186 G263 S266 K273 N278 E279 N282 R301 T315 S317 I319 S376 W382 N519 T522 K523 K524 R542 G543 D545 N547 K548 Y597 P599 K603 M604 L612 K613 N631 Y687 K689 K780 N782 G783 Q784 R949 R953 G960 T961 I962 K963 Q999 Q1000 S1037 F1038 |
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| Enzyme Commision number |
3.1.21.1: deoxyribonuclease I.
4.6.1.22: Bacillus subtilis ribonuclease. |
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