Structure of PDB 5x94 Chain A Binding Site BS02

Receptor Information
>5x94 Chain A (length=206) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLK
QPLNTT
Ligand information
>5x94 Chain N (length=13) Species: 102608 (Helicobacter pylori F32) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ASPEPIYATIDFD
Receptor-Ligand Complex Structure
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PDB5x94 Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K120 R138 V148 H169 V181 G182 G183 M202 V203 E204 T205
Binding residue
(residue number reindexed from 1)		K117 R135 V145 H156 V168 G169 G170 M189 V190 E191 T192
Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
External links
PDB RCSB:5x94, PDBe:5x94, PDBj:5x94
PDBsum5x94
PubMed28930683
UniProtQ06124|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)

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