Structure of PDB 5x7b Chain A Binding Site BS02
Receptor Information
>5x7b Chain A (length=206) Species:
9606
(Homo sapiens) [
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SRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVT
HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPL
NCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVR
TKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQ
PLNTTR
Ligand information
>5x7b Chain N (length=7) Species:
210
(Helicobacter pylori) [
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IYATIDD
Receptor-Ligand Complex Structure
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PDB
5x7b
Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Resolution
2.45 Å
Binding residue
(original residue number in PDB)
R138 S140 Q141 S142 V148 H169 V170 M171 E204 T205
Binding residue
(residue number reindexed from 1)
R136 S138 Q139 S140 V146 H155 V156 M157 E190 T191
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
External links
PDB
RCSB:5x7b
,
PDBe:5x7b
,
PDBj:5x7b
PDBsum
5x7b
PubMed
28930683
UniProt
Q06124
|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)
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