Structure of PDB 5x70 Chain A Binding Site BS02

Receptor Information

>5x70 Chain A (length=779) Species: 142805 (Rice dwarf virus (isolate O))

DYCIPNFSQTVNERTIIDIFTICRYRSPLVVFCLSHNELAKKYAQDVSMS
SGTHVHIIDGSVEITVSLYRTFRTIATQLLGRMQIVVFVTVDKSVVSTQV
MKSIAWAFRGSFVELRNQSVDSSTLVSKLENLVSFAPLYNVPKCGPDYYG
PTVYSELLSLATNARTHWYATIDYSMFTRSVLTGFVAKYFNEEAVPIDKR
IVSIVGYNPPYVWTCLRHGIRPTYIEKSLPNPGGKGPFGLILPVIHNPQI
KLLCLDTFMLSTSMNILYIGAYPATHLLSLQLNGWTILAFDPKITSDWTD
AMAKATGAKVIGVSKEFDFKSFSVQANQLNMFQNSKLSVIDDTWVETDYE
KFQSEKQAYFEWLIDRTSIDVRLISMKWNRSKDTSVSHLLALLPQPYGAS
IREMRAFFHKKGASDIKILAAETEKYMDDFTAMSVSDQINTQKFMHCMIT
TVGDALKMDLDGGRAVIASYSLSNSSNSKERVLKFLSDANKAKAMVVFGA
PNTHRLAYAKKVGLVLDSAIKMSKDLITFSNWRDYGYSQSELYDAGYVEI
TIDQMVAYSSDVYNGVGYFANSTYNDLFSWYIPKWYVHKRMLMQDIRLSP
AALVKCFTTLIRNICYVPHETYYRFRGILVDKYLRSKNVDPSQYSIVGSG
SKTFTVLSHFEVPHECGPLVFEASTDVNISGHLLSLAIAAHFVASPMILW
AEQMKYMAVDRMLPPNLDKSLFFDNKVTPSGALQRWHSREEVLLAAEICE
SYAAMMLNNKHSPDIIGTLKSAINLVFKI

Ligand information

>5x70 Chain G (length=2)

gc

..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5x70 Crystal structure of capping enzyme from Rice dwarf virus
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): D50 V137
• Binding residue (residue number reindexed from 1): D46 V133

Enzymatic activity

• Enzyme Commision number: 2.7.7.50: mRNA guanylyltransferase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004484 mRNA guanylyltransferase activity
• GO:0005525 GTP binding
• GO:0016779 nucleotidyltransferase activity

Biological Process

• GO:0006370 7-methylguanosine mRNA capping

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0044423 virion component

External links

• PDB: RCSB:5x70, PDBe:5x70, PDBj:5x70
• PDBsum: 5x70
• UniProt: P14583|MCE_RDVA Putative mRNA-capping enzyme P5