Structure of PDB 5x6c Chain A Binding Site BS02

Receptor Information
>5x6c Chain A (length=539) Species: 243232 (Methanocaldococcus jannaschii DSM 2661) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRFDIKKVLELAEKDFETAWRETRALIKDKHIDNKYPRLKPVYGKPHPVM
ETIERLRQAYLRMGFEEMINPVIVDEMEIYKQFGPEAMAVLDRCFYLAGL
PRPDVGLGNEKVEIIKNLGIDIDEEKKERLREVLHLYKKGAIDGDDLVFE
IAKALNVSNEMGLKVLETAFPEFKDLKPESTTLTLRSHMTSGWFITLSSL
IKKRKLPLKLFSIDRCFRREQREDRSHLMSYHSASCVVVGEDVSVDDGKV
VAEGLLAQFGFTKFKFKPDEKKSKYYTPETQTEVYAYHPKLGEWIEVATF
GVYSPIALAKYNIDVPVMNLGLGVERLAMIIYGYEDVRAMVYPQFYEYRL
SDRDIAGMIRVDKVPILDEFYNFANELIDICIANKDKESPCSVEVKREFN
FNGERRVIKVEIFENEPNKKLLGPSVLNEVYVYDGNIYGIPPTFEGVKEQ
YIPILKKAKEEGVSTNIRYIDGIIYKLVAKIEEALVSNVDEFKFRVPIVR
SLSDINLKIDELALKQIMGENKVIDVRGPVFLNAKVEIK
Ligand information
>5x6c Chain F (length=26) Species: 243232 (Methanocaldococcus jannaschii DSM 2661) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
NHMRVEYSKDLIRKGISTISQLKKAK
Receptor-Ligand Complex Structure
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PDB5x6c Structural basis for tRNA-dependent cysteine biosynthesis
Resolution3.101 Å
Binding residue
(original residue number in PDB)		I376 D378 E379 F411 N412 E414 R416 V496 N498 D500
Binding residue
(residue number reindexed from 1)		I366 D368 E369 F401 N402 E404 R406 V486 N488 D490
Enzymatic activity
Enzyme Commision number 6.1.1.27: O-phosphoserine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0043816 phosphoserine-tRNA(Cys) ligase activity
Biological Process
GO:0006412 translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x6c, PDBe:5x6c, PDBj:5x6c
PDBsum5x6c
PubMed29142195
UniProtQ59054|SEPS_METJA O-phosphoserine--tRNA(Cys) ligase (Gene Name=sepS)

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