Structure of PDB 5x5h Chain A Binding Site BS02

Receptor Information

>5x5h Chain A (length=385) Species: 196627 (Corynebacterium glutamicum ATCC 13032)

FDPNTQGFSTASIHAGYEPDDYYGSINTPIYASTTFAQNAPNELRKGYEY
TRVGNPTIVALEQTVAALEGAKYGRAFSSGMAATDILFRIILKPGDHIVL
GNDAYGGTYRLIDTVFTAWGVEYTVVDTSVVEEVKAAIKDNTKLIWVETP
TNPALGITDIEAVAKLTEGTNAKLVVDNTFASPYLQQPLKLGAHAVLHST
TKYIGGHSDVVGGLVVTNDQEMDEELLFMQGGIGPIPSVFDAYLTARGLK
TLAVRMDRHCDNAEKIAEFLDSRPEVSTVLYPGLKNHPGHEVAAKQMKRF
GGMISVRFAGGEEAAKKFCTSTKLICLAESLGGVESLLEHPATMTHQSAA
GSQLEVPRDLVRISIGIEDIEDLLADVEQALNNLH

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5x5h Chain A Residue 405

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5x5h Structural Insights into Substrate Specificity of Cystathionine gamma-Synthase from Corynebacterium glutamicum
• Resolution: 1.51 Å
• Binding residue (original residue number in PDB): E71 Q189 P190 L191
• Binding residue (residue number reindexed from 1): E69 Q187 P188 L189
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): R54 Y107 D179 K204
• Catalytic site (residue number reindexed from 1): R52 Y105 D177 K202
• Enzyme Commision number: 2.5.1.48: cystathionine gamma-synthase.

Gene Ontology

Molecular Function

• GO:0003962 cystathionine gamma-synthase activity
• GO:0016740 transferase activity
• GO:0016846 carbon-sulfur lyase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0046872 metal ion binding

Biological Process

• GO:0009086 methionine biosynthetic process
• GO:0019346 transsulfuration

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5x5h, PDBe:5x5h, PDBj:5x5h
• PDBsum: 5x5h
• PubMed: 28675039
• UniProt: Q79VD9