Structure of PDB 5wze Chain A Binding Site BS02

Receptor Information

>5wze Chain A (length=442) Species: 208964 (Pseudomonas aeruginosa PAO1)

MIRIPKSEYARRRKALMAQMEPNSIAILPAAPMYIRNRDVEHVYRQDSDF
QYLTGFPEPEAVMALIPGRAHGEYVLFCRERDPERELWDGLRAGQDGAIG
QYGADDAFPIGDIDDILPGLIEGRDRVYYALGANPDFDRRLMDWINVIRS
KARQGAQPPNEFVALDHLLHDQRLYKSANEVKVMRYAAEVSARAHIRAME
VCRPGLFEYHLEAELEYEFRKGGAKMPAYGSIVAAGRNACILHYRENDAA
IKDGDLILIDAGCEIDCYASDITRTFPANGRFSPEQKAIYELVLEANMAA
FDYIAPGRHWNEAHEATVRVITAGLVRLGLLEGDVDELIAHEAYKAFYMH
RAGHWLGMDVHDVGEYRVGGEWRVLEPGMAMTVEPGIYIAPDNTTVAKKW
RGIGVRIEDDVVVTRNGCEVLTNGVPKTVAEIEALMAAAKSE

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5wze Chain A Residue 507

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5wze Structure-Function Relationship of Aminopeptidase P from Pseudomonas aeruginosa.
• Resolution: 1.783 Å
• Binding residue (original residue number in PDB): Y229 D260 D271 E408
• Binding residue (residue number reindexed from 1): Y229 D260 D271 E408
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008237 metallopeptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:5wze, PDBe:5wze, PDBj:5wze
• PDBsum: 5wze
• PubMed: 29259588
• UniProt: Q9HTW6