Structure of PDB 5wz3 Chain A Binding Site BS02

Receptor Information
>5wz3 Chain A (length=565) Species: 64320 (Zika virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMKIIGNRIERIRSEHAETWFFDENHPYRTWAYHGSYEAPLINGVVRLLS
KPWDVVTGVTGITTPYGQQRVFKEKVDTRVPDPQEGTRQVMSMVSSWLWK
ELGKHKRPRVCTKEEFINKVRSEAVNDPRFWALVDKEREHHLRGECQSCV
YNMWYMWLGARFLEFEALGFLNEDHWMGRENSGGGVEGLGLQRLGYVLEE
MSRIPGGRMYADDTAGWDTRISRFDLENEALITNQMEKGHRALALAIIKY
TYQNKVVKVLRPAEKGKTVMDIISRQDQRGSGQVVTYALNTFTNLVVQLI
RNMEAEEVLEMQDLWLLRRSEKVTNWLQSNGWDRLKRMAVSGDDCVVKPI
DDRFAHALRFLNDMGKVRKDTQEWKPSTGWDNWEEVPFCSHHFNKLHLKD
GRSIVVPCRHQDELIGRARVSPGAGWSIRETACLAKSYAQMWQLLYFHRR
DLRLMANAICSSVPVDWVPTGRTTWSIHGKGEWMTTEDMLVVWNRVWIEE
NDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGHRPRTTWAENIKNTVNMV
RRIIGDEEKYMDYLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5wz3 Chain A Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wz3 The crystal structure of Zika virus NS5 reveals conserved drug targets.
Resolution1.804 Å
Binding residue
(original residue number in PDB)		E439 H443 C448 C451
Binding residue
(residue number reindexed from 1)		E137 H141 C146 C149
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5wz3, PDBe:5wz3, PDBj:5wz3
PDBsum5wz3
PubMed28254839
UniProtA0A109PRQ3

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