Structure of PDB 5wun Chain A Binding Site BS02

Receptor Information

>5wun Chain A (length=426) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

Ligand information

>5wun Chain C (length=6) Species: 10377 (Human herpesvirus 4 strain B95-8) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EKRPRS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5wun Structural basis for the regulation of nuclear import of Epstein-Barr virus nuclear antigen 1 (EBNA1) by phosphorylation of the nuclear localization signal.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238
Binding residue (residue number reindexed from 1)	W71 N75 S78 G79 T84 Q110 W113 N117 D121 W160 R167

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5wun, PDBe:5wun, PDBj:5wun
PDBsum	5wun
PubMed	28104399
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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