Structure of PDB 5wsl Chain A Binding Site BS02

Receptor Information

>5wsl Chain A (length=282) Species: 1339250 (Meiothermus taiwanensis WR-220)

ATQTGATWGLDRIDQRTLPLSGTFTYSNTGSGVNAYIIDTGIRVSHSEFG
GRATAVFDAIGDGQNGNDCNGHGTHVAGTVGGTVYGVAKSVRLYAVRVLN
CSGSGSNSGVIAGVDWVRQNARRPAVANMSLGGGASSALDTAVNNAINAG
ITFALAAGNSNRDACQFSPARVTAGITVGATTSTDARASYSNYGSCLDLF
APGSSITSAWISSDTSTNTISGTSMATPHVAGVAALYLQSNPSASPATVR
NAIVGNATSGVVSNAGRRSPNLLLYSNYENLY

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5wsl Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5wsl The discovery of novel heat-stable keratinases from Meiothermus taiwanensis WR-220 and other extremophiles
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): V172 T173 G175 T177
• Binding residue (residue number reindexed from 1): V172 T173 G175 T177
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): D39 H72 N159 S224
• Catalytic site (residue number reindexed from 1): D39 H72 N159 S224

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005615 extracellular space

External links

• PDB: RCSB:5wsl, PDBe:5wsl, PDBj:5wsl
• PDBsum: 5wsl
• PubMed: 28680127
• UniProt: A0A2H4A2Y5