Structure of PDB 5wno Chain A Binding Site BS02

Receptor Information

>5wno Chain A (length=302) Species: 6239 (Caenorhabditis elegans)

CLIPSSELQTKLDKKLGAGAFGTVFAGIYYPKRANVKIPVAIKVFQTDQS
QTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLK
LHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEI
TDFGLSKILKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPY
QGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILY
ERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYF
DQ

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5wno Chain A Residue 1202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5wno Regulation of Kinase Activity in the Caenorhabditis elegans EGF Receptor, LET-23.
• Resolution: 2.386 Å
• Binding residue (original residue number in PDB): N1015 D1028
• Binding residue (residue number reindexed from 1): N139 D152
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D1010 R1014 N1015 D1028
• Catalytic site (residue number reindexed from 1): D134 R138 N139 D152
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5wno, PDBe:5wno, PDBj:5wno
• PDBsum: 5wno
• PubMed: 29358026
• UniProt: P24348|LET23_CAEEL Receptor tyrosine-protein kinase let-23 (Gene Name=let-23)