Structure of PDB 5w6k Chain A Binding Site BS02

Receptor Information
>5w6k Chain A (length=522) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDL
KEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYG
GEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAHVE
ATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERVLF
DELGLPAIGKTEKTGKRSTSAAVLEALREAHAIVEKILQYRELTKLKSTY
IDPLPELIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIR
RAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASW
MFGVPREAVDPLMRRAAKTINFGVLYGMSAHRLSQELAIPFPKVRAWIEK
TLEEGRRRGYVETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAAD
LMKLAMVKLFPRLEEMGARMLLQVHDELVLEAPKERAEAVARLAKEVMEG
VYPLAVPLEVEVGIGEDWLSAK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5w6k Snapshots of an evolved DNA polymerase pre- and post-incorporation of an unnatural nucleotide.
Resolution2.339 Å
Binding residue
(original residue number in PDB)		N483 N485 S486 S543 T544 T569 A570 T571 R573 S575 S576 S577 D578 N580 G668 Y671 M673 S674 R677 R728 R746 M747 N750 Q754
Binding residue
(residue number reindexed from 1)		N188 N190 S191 S248 T249 T274 A275 T276 R278 S280 S281 S282 D283 N285 G373 Y376 M378 S379 R382 R419 R437 M438 N441 Q445
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5w6k, PDBe:5w6k, PDBj:5w6k
PDBsum5w6k
PubMed29986111
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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