Structure of PDB 5w1d Chain A Binding Site BS02

Receptor Information

>5w1d Chain A (length=405) Species: 10090 (Mus musculus)

PSYQGYILESAPVGATISESLNLTTPLRIVALELHLFLNDYTSVFTVTPT
GITRYLTLLQPVDREEQQTYTFLITAFDGVQESEPVVVNIRVMDANDNTP
TFPEISYDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGDFV
INKTTGLVSIAPGVELIVGQTYALTVQASDNAPPAERRHSICTVYIEVLP
PNNQSPPRFPQLMYSLEVSEAMRIGAILLNLQATDREGDPITYAIENGDP
QRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVV
TDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLG
NFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYI
KVLDI

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5w1d Chain A Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5w1d Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception.
• Resolution: 3.35 Å
• Binding residue (original residue number in PDB): E606 E658 D688 V689 D691 D724
• Binding residue (residue number reindexed from 1): E220 E272 D302 V303 D305 D338
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5w1d, PDBe:5w1d, PDBj:5w1d
• PDBsum: 5w1d
• PubMed: 32963095
• UniProt: Q99PJ1|PCD15_MOUSE Protocadherin-15 (Gene Name=Pcdh15)