BioLiP

Receptor Information

>5vu8 Chain A (length=757) Species: 311400 (Thermococcus kodakarensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MILDTDYITEDGKPVIRIFKKENGEFKIEYDRTFEPYFYALLKDDSAIEE
VKKITAERHGTVVTVKRVEKVQKKFLGRPVEVWKLYFTHPQDVPAIRDKI
REHPAVIDIYEYDIPFAKRYLIDKGLVPMEGDEELKMLAFAIATLYHEGE
EFAEGPILMISYADEEGARVITWKNVDLPYVDVVSTEREMIKRFLRVVKE
KDPDVLITYNGDNFDFAYLKKRCEKLGINFALGRDGSEPKIQRMGDRFAV
EVKGRIHFDLYPVIRRTINLPTYTLEAVYEAVFGQPKEKVYAEEITTAWE
TGENLERVARYSMEDAKVTYELGKEFLPMEAQLSRLIGQSLWDVSRSSTG
NLVEWFLLRKAYERNELAPNKPDEKELARRRQSYEGGYVKEPERGLWENI
VYLDFRSLYPSIIITHNVSPDTLNREGCKEYDVAPQVGHRFCKDFPGFIP
SLLGDLLEERQKIKKKMKATIDPIERKLLDYRQRRIKILANSYYGYYGYA
RARWYCKECAESVTAWGREYITMTIKEIEEKYGFKVIYSDTDGFFATIPG
ADAETVKKKAMEFLKYINAKLPGALELEYEGFYKRGFFVTKKKYAVIDEE
GKITTRGLEIVRRDWSEIAKETQARVLEALLKDGDVEKAVRIVKEVTEKL
SKYEVPPKLVIHIQITRDLKDYKATGPHVAVAKRLAAGVKIRPGTVISYI
VLKGSGRIGDRAIPFDEFDPTKHKYDAEYYIENQVLPAVERILRAFGYRK
EDLRYQK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5vu8 Structural basis for TNA synthesis by an engineered TNA polymerase.
Resolution	3.2 Å
Binding residue (original residue number in PDB)	D540 T541 K592 R606 G607 R612 I664 Q665 Y673 H679
Binding residue (residue number reindexed from 1)	D540 T541 K592 R606 G607 R612 I663 Q664 Y672 H678

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006260	DNA replication
GO:0071897	DNA biosynthetic process

PDB	RCSB:5vu8, PDBe:5vu8, PDBj:5vu8
PDBsum	5vu8
PubMed	29180809
UniProt	D0VWU9

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Structure of PDB 5vu8 Chain A Binding Site BS02