Structure of PDB 5vlh Chain A Binding Site BS02

Receptor Information
>5vlh Chain A (length=355) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTK
ILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQGGSLVEVY
LLDTSIQSDHREIEGRVMVTDFENVPEEDSKCDSHGTHLAGVVSGRDAGV
AKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAG
GYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNA
QDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAH
VAGIAAMMLSAEPELTLAELRQRLIHFSAKDVINEAWFPEDQRVLTPNLV
AALPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5vlh Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Resolution2.86 Å
Binding residue
(original residue number in PDB)		D238 A239 I369 T377 C378 F379 V380
Binding residue
(residue number reindexed from 1)		D147 A148 I278 T286 C287 F288 V289
Enzymatic activity
Catalytic site (original residue number in PDB) D186 H226 N317 S386
Catalytic site (residue number reindexed from 1) D103 H135 N226 S295
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5vlh, PDBe:5vlh, PDBj:5vlh
PDBsum5vlh
PubMed28825733
UniProtQ8NBP7|PCSK9_HUMAN Proprotein convertase subtilisin/kexin type 9 (Gene Name=PCSK9)

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