Structure of PDB 5uz8 Chain A Binding Site BS02

Receptor Information

>5uz8 Chain A (length=317) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DNTPQFKPFGITYYTERVLEGATPGTTLIAVAAVDPDKGLNGLITYTLLD
LTPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIP
VYLEIVDINDNNPIFDQPSYQEAVFEDIAVGTVILRVTATDADSGNFALI
EYSLVDGEGKFAINPNTGDISVLSSLDREKKDHYILTALAKDNPGDVASN
RRENSVQVVIRVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMLATDQD
EGSNSQLTYSLEGPGMEAFSVDMDSGLVTTQRPLQSYERFNLTVVATDGG
EPPLWGTTMLLVEVIDV

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

5uz8 Chain A Residue 2605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5uz8 Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Resolution	1.85 Å
Binding residue (original residue number in PDB)	E2390 E2443 D2478 V2479 D2481 D2514
Binding residue (residue number reindexed from 1)	E126 E179 D214 V215 D217 D250
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:5uz8, PDBe:5uz8, PDBj:5uz8
PDBsum	5uz8
PubMed	30033219
UniProt	Q99PF4\|CAD23_MOUSE Cadherin-23 (Gene Name=Cdh23)

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