Structure of PDB 5uq6 Chain A Binding Site BS02

Receptor Information

>5uq6 Chain A (length=301) Species: 9823 (Sus scrofa)

TPILRFVAVGDWGGVPNAPFHTAREMANAKAIATTVKTLGADFILSLGDN
FYFTGVHDAKDKRFQETFEDVFSDPSLRNVPWHVLAGNHDHLGNVSAQIA
YSKISKRWNFPSPYYRLRFKIPRSNVSVAIFMLDTVTLCGNSDDFVSQQP
ERPRNLALARTQLAWIKKQLAAAKEDYVLVAGHYPVWSIAEHGPTHCLVK
QLLPLLTTHKVTAYLCGHDHNLQYLQDENGLGFVLSGAGNFMDPSKKHLR
KVPNGYLRFHFGAENSLGGFAYVEITPKEMSVTYIEASGKSLFKTKLPRR
A

Ligand information

• Ligand ID: FE
• InChI: InChI=1S/Fe/q+3
• InChIKey: VTLYFUHAOXGGBS-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Fe+3]
• Formula: Fe
• Name: FE (III) ION
• DrugBank: DB13949
• PDB chain: 5uq6 Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5uq6 Visualization of the Reaction Trajectory and Transition State in a Hydrolytic Reaction Catalyzed by a Metalloenzyme.
• Resolution: 1.182 Å
• Binding residue (original residue number in PDB): D52 N91 H186 H221
• Binding residue (residue number reindexed from 1): D49 N88 H183 H218
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.1.3.2: acid phosphatase.

Gene Ontology

Molecular Function

• GO:0003993 acid phosphatase activity
• GO:0008198 ferrous iron binding
• GO:0008199 ferric iron binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006826 iron ion transport
• GO:0045453 bone resorption

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:5uq6, PDBe:5uq6, PDBj:5uq6
• PDBsum: 5uq6
• PubMed: 28261912
• UniProt: P09889|PPA5_PIG Tartrate-resistant acid phosphatase type 5 (Gene Name=ACP5)