Structure of PDB 5um9 Chain A Binding Site BS02

Receptor Information
>5um9 Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFNGKPPQLKSGELAKRS
ERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIP
YLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKK
LPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQ
KHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEP
NEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTLEVLFQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5um9 Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Resolution2.805 Å
Binding residue
(original residue number in PDB)		G2 K8 Y40 N86 K93 R100 K135 N138 E160 E178 D179 R192 Y268
Binding residue
(residue number reindexed from 1)		G1 K7 Y39 N85 K92 R99 K134 N137 E159 E177 D178 R191 Y267
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:5um9, PDBe:5um9, PDBj:5um9
PDBsum5um9
PubMed28653660
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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