Structure of PDB 5ulx Chain A Binding Site BS02

Receptor Information
>5ulx Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKDVMTPMVDI
LMKLFRNMVNVLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB5ulx Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Resolution1.96 Å
Binding residue
(original residue number in PDB)		Q59 K60 V64 L99 R103 Q300 S303 E305 S307 R347
Binding residue
(residue number reindexed from 1)		Q34 K35 V39 L74 R78 Q275 S278 E280 S282 R322
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5ulx, PDBe:5ulx, PDBj:5ulx
PDBsum5ulx
PubMed28272441
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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