Structure of PDB 5u5p Chain A Binding Site BS02

Receptor Information

>5u5p Chain A (length=426) Species: 10090 (Mus musculus)

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

Ligand information

>5u5p Chain B (length=10) Species: 9606 (Homo sapiens)

SNPRKRHRED

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5u5p DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.
• Resolution: 2.171 Å
• Binding residue (original residue number in PDB): L104 S105 W142 N146 S149 G150 T151 T155 Q181 W184 N188 G191 D192 N228 W231 R238 W273
• Binding residue (residue number reindexed from 1): L33 S34 W71 N75 S78 G79 T80 T84 Q110 W113 N117 G120 D121 N157 W160 R167 W202

Enzymatic activity

• Catalytic site (original residue number in PDB): T151 A163 N361 R366 Q367
• Catalytic site (residue number reindexed from 1): T80 A92 N290 R295 Q296

Gene Ontology

Molecular Function

• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5u5p, PDBe:5u5p, PDBj:5u5p
• PDBsum: 5u5p
• PubMed: 29175432
• UniProt: P52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)