Structure of PDB 5u5n Chain A Binding Site BS02

Receptor Information

>5u5n Chain A (length=279) Species: 88036 (Selaginella moellendorffii)

VLAAAPVMVNDCTGKVGQAVAEAAVAAGLRLVPLSLTGPGRGGKRVVIGN
VEVDVREVSEREDVVKEVITEYPNVIVVDYTLPAAVNDNAEFYCKQGLPF
VMGTTGGDREKLLDVARKSGTYSIIAPQMGKQVVAFVAAMEIMAKQFPGA
FSGYTLQVTESHQSTKADVSGTALAVISSLRKLGLDFKDEQVELVRDPKE
QMTRMGVPEQHLNGHAFHTYKIISPDGTVFFEFKHNVCGRSIYAQGTVDA
VLFLSKKIQEKSEKRLYNMIDVLEGGSMR

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5u5n Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5u5n Plant DHDPR forms a dimer with unique secondary structure features that preclude higher-order assembly.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): T22 R50 K53
• Binding residue (residue number reindexed from 1): T13 R41 K44
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase
• GO:0016491 oxidoreductase activity
• GO:0070402 NADPH binding

Biological Process

• GO:0009085 lysine biosynthetic process
• GO:0009089 lysine biosynthetic process via diaminopimelate
• GO:0019877 diaminopimelate biosynthetic process

Cellular Component

• GO:0009570 chloroplast stroma

External links

• PDB: RCSB:5u5n, PDBe:5u5n, PDBj:5u5n
• PDBsum: 5u5n
• PubMed: 29187521
• UniProt: D8R6G2