Structure of PDB 5u33 Chain A Binding Site BS02

Receptor Information
>5u33 Chain A (length=1085) Species: 1356854 (Alicyclobacillus acidoterrestris ATCC 49025) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMAVKSIKVKLRLDDMPEIRAGLWKLHKEVNAGVRYYTEWLSLLRQENLY
RRSPNGDGEQECDKTAEECKAELLERLRARQVENGHRGPAGSDDELLQLA
RQLYELLVPQAIGAKGDAQQIARKFLSPLADKDAVGGLGIAKAGNKPRWV
RMREAGEWEEEKEKAETRKSADRTADVLRALADFGLKPLMRVYTDSEMSS
VEWKPLRKGQAVRTWDRDMFQQAIERMMSWESWNQRVGQEYAKLVEQKNR
FEQKNFVGQEHLVHLVNQLQQDMKEASPGLESKEQTAHYVTGRALRGSDK
VFEKWGKLAPDAPFDLYDAEIKNVQRRNTRRFGSHDLFAKLAEPEYQALW
REDASFLTRYAVYNSILRKLNHAKMFATFTLPDATAHPIWTRFDKLGGNL
HQYTFLFNEFGERRHAIRFHKLLKVENGVAREVDDVTVPISMSEQLDNLL
PRDPNEPIALYFRDYGAEQHFTGEFGGAKIQCRRDQLAHMHRRRRDVYLN
VSVRVQSQSEARGERRPPYAAVFRLVGDNHRAFVHFDKLSDYLAEHPDDG
KLGSEGLLSGLRVMSVALGLRTSASISVFRVARKDELKPNSKGRVPFFFP
IKGNDNLVAVHERSQLLKLPGETESKDLRAIREERQRTLRQLRTQLAYLR
LLVRCGSEDVGRRERSWAKLIEQPVDAANHMTPDWREAFENELQKLKSLH
GICSDKEWMDAVYESVRRVWRHMGKQVRDWRKDVRSGERPKIRGYAKDVV
GGNSIEQIEYLERQYKFLKSWSFFGKVSGQVIRAEKGSRFAITLREHIDH
AKEDRLKKLADRIIMEALGYVYALDERGKGKWVAKYPPCQLILLAELSEY
QFNNDRPPSENNQLMQWSHRGVFQELINQAQVHDLLVGTMYAAFSSRFDA
RTGAPGIRCRRVPARCTQEHNPEPFPWWLNKFVVEHTLDACPLRADDLIP
TGEGEIFVSPFSAEEGDFHQIHAALNAAQNLQQRLWSDFDISQIRLRCDW
GEVDGELVLIPRLTGKRTADSYSNKVFYTNTGVTYYERERGREKSVVLMR
DPSGIINRGNWTRQKEFWSMVNQRIEGYLVKQIRS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5u33 PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.
Resolution3.75 Å
Binding residue
(original residue number in PDB)
A117 Q118 A142 G143 N144 K209 E226 S230 S233 W234 G280 L281 K284 E285 A288 H289 R294 R297 T330 G334 S335 K396 N400 G478 S505 R507 R646 R786 A787 E788 K789 S791 R792 F793 R798 K805 F855 P861 S862 M868 S871 R873 G874
Binding residue
(residue number reindexed from 1)
A118 Q119 A143 G144 N145 K208 E225 S229 S232 W233 G279 L280 K283 E284 A287 H288 R293 R296 T329 G333 S334 K395 N399 G477 S502 R504 R643 R783 A784 E785 K786 S788 R789 F790 R795 K802 F852 P858 S859 M865 S868 R870 G871
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
Biological Process
GO:0051607 defense response to virus

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Molecular Function

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Biological Process
External links
PDB RCSB:5u33, PDBe:5u33, PDBj:5u33
PDBsum5u33
PubMed27984729
UniProtT0D7A2|CS12B_ALIAG CRISPR-associated endonuclease Cas12b (Gene Name=cas12b)

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