Structure of PDB 5tvg Chain A Binding Site BS02

Receptor Information

>5tvg Chain A (length=468) Species: 269482 (Burkholderia vietnamiensis G4)

HHHHHMSRLIVVSNRVAAGEDTRPSAGGLAVGVMDALKQTGGVWFGWNGE
IVGTPDAAPAVRRDGNVTYATLGLTRRDYDQYYRGFSNATLWPVFHYRSD
LARFDRQEYAGYLRVNAMLARQLAALLRPDDLIWVHDYHLLPFAHCLREL
GVKNPIGFFLHIPFPSPDMLRVVPPHDELVKFMCAYDIAGFQTDADKRAF
SDYIERRGIGTASDDGMLHAHGRVVKVAAYPIGVYPDAIAEAAVQYGGRK
PVKMLRDALGGRKLVMSVDRLDYSKGLVERFQSFERMLAGAPDWQGRVSF
VQIAPPTRSDVQTYQRIRETLEREAGRINGRFAQLDWTPIQYLNRKYERN
LLMAFFRMSQVGYVTPLRDGMNLVAKEYVASQDPADPGVLVLSEFAGAAA
ELGGALLVNPYDHAQMADALARALAMPLAERQARHEENLAQLRNNDLSVW
RDTFVADLRSVAAAASVT

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5tvg Chain A Residue 507

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5tvg Crystal structure of an alpha,alpha-trehalose-phosphate synthase (UDP-forming) from Burkholderia vietnamiensis
• Resolution: 2.3 Å
• Binding residue (original residue number in PDB): R352 S354 Q377
• Binding residue (residue number reindexed from 1): R357 S359 Q382
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H156 D364
• Catalytic site (residue number reindexed from 1): H161 D369
• Enzyme Commision number: 2.4.1.15: alpha,alpha-trehalose-phosphate synthase (UDP-forming).

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
• GO:0016757 glycosyltransferase activity
• GO:0016758 hexosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005992 trehalose biosynthetic process

External links

• PDB: RCSB:5tvg, PDBe:5tvg, PDBj:5tvg
• PDBsum: 5tvg
• UniProt: A4JGS8