Structure of PDB 5tuz Chain A Binding Site BS02

Receptor Information

>5tuz Chain A (length=259) Species: 9606 (Homo sapiens)

VERIVSRDIARGYERIPIPCVNAVDSEPCPSNYKYVSQNCVTSPMNIDRN
ITHLQYCVCIDDCSSSNCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFEC
NHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEY
VGELISDSEADVREEDSYLFDLDNGEVYCIDARFYGNVSRFINHHCEPNL
VPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLGFDYGERFWDIKGKLFSCR
CGSPKCRHS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5tuz Chain A Residue 3002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5tuz Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase.
• Resolution: 1.95 Å
• Binding residue (original residue number in PDB): C1062 C1075 C1105 C1109
• Binding residue (residue number reindexed from 1): C57 C70 C100 C104
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): Y1155 Y1242
• Catalytic site (residue number reindexed from 1): Y150 Y235
• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Gene Ontology

Molecular Function

• GO:0002039 p53 binding
• GO:0008270 zinc ion binding
• GO:0016279 protein-lysine N-methyltransferase activity
• GO:0042054 histone methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:5tuz, PDBe:5tuz, PDBj:5tuz
• PDBsum: 5tuz
• PubMed: 28135087
• UniProt: Q9H9B1|EHMT1_HUMAN Histone-lysine N-methyltransferase EHMT1 (Gene Name=EHMT1)