Structure of PDB 5tj6 Chain A Binding Site BS02

Receptor Information
>5tj6 Chain A (length=890) Species: 6500 (Aplysia californica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RQWYSFLASSLVTFGSGLVVIIIYRIVLWLCGWMTEAKDWAGELISGQTT
TGRILVGLVFLLSIASLIIYFIDASTNSSSTTQQVDLAFNVFFMIYFFIR
FVAANDKLWFWVELFSFVDYFTIPPSFVAIYLDRNWLGLRFLRALRLMSI
PDILTYLNVLKTSTLIRLVQLVVSFVSLWLTAAGFLHLLENSGDPFFDFG
NAQHLTYWECLYFLMVTMSTVGFGDIFATTVLGRTFVVIFIMIFIGLFAS
FIPEIAEILGKRQKYGGSYKKERGKRHVVVCGYITFDSVSNFLKDFLHKD
REDVDVEIVFLHKGLPGLELEGLLKRHFTQVEYFWGSVMDANDLERVKIQ
EADACLVLANKYCQDPDQEDAANIMRVISIKNYHSDIKVIVQLLQYHNKA
YLLNIPSWDWKRGDDAVCVAELKLGFIAQSCLAPGFSTLMANLFTMRSYK
PTPEMSQWQTDYMRGTGMEMYTEYLSSAFNALTFPEAAELCFSKLKLLLL
AIEVRESTLAINPGPKVKIENATQGFFIAESAEEVKRAFYYCKNCHANVS
DVRQIKKCKCRKFDSTGMFHWCPDRPLNDCLQDRSQASASGLRNHVVVCL
FADAASPLIGLRNLVMPLRASNFHYHELKPTIIVGNLDYLHREWKTLQNF
PKLSILPGSPLNRANLRAVNINLCDMCVIVSAKDRNMEDPNLVDKEAILC
SLNIKAMTFDDAGANVPLITELANDSNVQFLDQDDDDDPDTELYMTQPFA
CGTAFAVSVLDSLMSTSYFNDNALTLIRTLITGGATPELEQILAEGAGMR
GGYCSPAVLANRDRCRVAQISLFDGPLAQFGQGGHYGELFVYALRHFGIL
CIGLYRFRDTNPSSKRYVITNPPEDFPLLPTDQVYVLTYK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5tj6 Chain A Residue 1108 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tj6 Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel.
Resolution3.5 Å
Binding residue
(original residue number in PDB)		Q899 D902 D905 D907
Binding residue
(residue number reindexed from 1)		Q729 D732 D735 D737
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005267 potassium channel activity
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5tj6, PDBe:5tj6, PDBj:5tj6
PDBsum5tj6
PubMed27974795
UniProtQ5QJC5

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