Structure of PDB 5t4i Chain A Binding Site BS02

Receptor Information
>5t4i Chain A (length=297) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADR
KHCKFKPDPNIPPTFSAFNEDYVGSGWSRGAMAPAGNNKFSSKAMAETFY
LSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGK
KIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQ
PQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTL
YLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLEELKA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t4i A domain in human EXOG converts apoptotic endonuclease to DNA-repair exonuclease.
Resolution2.389 Å
Binding residue
(original residue number in PDB)		D169 S172 L311 K315
Binding residue
(residue number reindexed from 1)		D110 S113 L252 K256
Enzymatic activity
Catalytic site (original residue number in PDB) C112 A140 N162 N171 E179
Catalytic site (residue number reindexed from 1) C53 A81 N103 N112 E120
Enzyme Commision number 3.1.30.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5t4i, PDBe:5t4i, PDBj:5t4i
PDBsum5t4i
PubMed28466855
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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