Structure of PDB 5oh7 Chain A Binding Site BS02

Receptor Information
>5oh7 Chain A (length=105) Species: 55518 (Magnetospirillum gryphiswaldense) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLR
LIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRL
AEGPA
Ligand information
Ligand IDHYN
InChIInChI=1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)
InChIKeyWJRBRSLFGCUECM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1CNC(=O)N1
ACDLabs 10.04O=C1NC(=O)NC1
OpenEye OEToolkits 1.5.0C1C(=O)NC(=O)N1
FormulaC3 H4 N2 O2
Nameimidazolidine-2,4-dione;
Hydantoin
ChEMBLCHEMBL122334
DrugBank
ZINCZINC000005133259
PDB chain5oh7 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5oh7 Chemical Ligand Space of Cereblon.
Resolution1.85 Å
Binding residue
(original residue number in PDB)		F77 W79 W85 W99 Y101
Binding residue
(residue number reindexed from 1)		F59 W61 W67 W81 Y83
Annotation score1
Binding affinityPDBbind-CN: -logKd/Ki=4.37,Ki=43uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5oh7, PDBe:5oh7, PDBj:5oh7
PDBsum5oh7
PubMed31459225
UniProtA4TVL0

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