Structure of PDB 5oh4 Chain A Binding Site BS02

Receptor Information
>5oh4 Chain A (length=105) Species: 55518 (Magnetospirillum gryphiswaldense) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLR
LIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRL
AEGPA
Ligand information
Ligand ID9UZ
InChIInChI=1S/C5H7NO2/c7-4-2-1-3-5(8)6-4/h1-3H2,(H,6,7,8)
InChIKeyKNCYXPMJDCCGSJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.6C1CC(=O)NC(=O)C1
CACTVS 3.385O=C1CCCC(=O)N1
FormulaC5 H7 N O2
Namepiperidine-2,6-dione
ChEMBLCHEMBL3763941
DrugBank
ZINCZINC000001530742
PDB chain5oh4 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5oh4 Chemical Ligand Space of Cereblon.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		F77 S78 W79 W85 W99 Y101
Binding residue
(residue number reindexed from 1)		F59 S60 W61 W67 W81 Y83
Annotation score1
Binding affinityPDBbind-CN: -logKd/Ki=4.55,Ki=28uM
BindingDB: Ki=28000nM,IC50=48900nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5oh4, PDBe:5oh4, PDBj:5oh4
PDBsum5oh4
PubMed31459225
UniProtA4TVL0

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