Structure of PDB 5oh3 Chain A Binding Site BS02

Receptor Information
>5oh3 Chain A (length=105) Species: 55518 (Magnetospirillum gryphiswaldense) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASIFRCRQCGQTISRRDWLLPMGGDHEHVVFNPAGMIFRVWCFSLAQGLR
LIGAPSGEFSWFKGYDWTIALCGQCGSHLGWHYEGGSQPQTFFGLIKDRL
AEGPA
Ligand information
Ligand ID9V2
InChIInChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)/t7-/m0/s1
InChIKeyHAPOVYFOVVWLRS-ZETCQYMHSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC[C]1(C)CC(=O)NC1=O
OpenEye OEToolkits 2.0.6CCC1(CC(=O)NC1=O)C
CACTVS 3.385CC[C@@]1(C)CC(=O)NC1=O
OpenEye OEToolkits 2.0.6CC[C@]1(CC(=O)NC1=O)C
FormulaC7 H11 N O2
Name(3~{S})-3-ethyl-3-methyl-pyrrolidine-2,5-dione
ChEMBL
DrugBank
ZINCZINC000001530805
PDB chain5oh3 Chain A Residue 202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5oh3 Chemical Ligand Space of Cereblon.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		N50 F77 W79 W85 W99 Y101
Binding residue
(residue number reindexed from 1)		N32 F59 W61 W67 W81 Y83
Annotation score1
Binding affinityPDBbind-CN: -logKd/Ki=3.87,Ki=136uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5oh3, PDBe:5oh3, PDBj:5oh3
PDBsum5oh3
PubMed31459225
UniProtA4TVL0

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