Structure of PDB 5of3 Chain A Binding Site BS02

Receptor Information

>5of3 Chain A (length=319) Species: 273057 (Saccharolobus solfataricus P2)

TNLIKSFFRNYYLNAELELPKDMELREFALQPFGSDTYVRHLSFSSSEEL
RDYLVNRNLPLHLFYSSARYQLPSARNMEEKAWMGSDLLFDIDADHLCKL
RSIRFCPVCGNAVVSEKCERDNVETLEYVEMTSECIKRGLEQTRNLVEIL
EDDFGLKPKVYFSGNRGFHVQVDCYGNCALLDSDERKEIAEYVMGIGVPG
YPGGSENAPGWVGRKNRGINGVTIDEQVTIDVKRLIRIPNSLHGKSGLIV
KRVPNLDDFEFNETLSPFTGYTIFLPYITIETEVLGSIIKLNRGIPIKIK
SSIGIYLHLRNLGEVKAYV

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5of3 Chain A Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5of3 Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster.
• Resolution: 2.906 Å
• Binding residue (original residue number in PDB): D101 D103
• Binding residue (residue number reindexed from 1): D91 D93
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.-

Gene Ontology

Molecular Function

• GO:0003896 DNA primase activity
• GO:0005515 protein binding
• GO:0016779 nucleotidyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006260 DNA replication
• GO:0006269 DNA replication, synthesis of primer

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex
• GO:1990077 primosome complex

External links

• PDB: RCSB:5of3, PDBe:5of3, PDBj:5of3
• PDBsum: 5of3
• PubMed: 29167441
• UniProt: Q97Z83|PRIS_SACS2 DNA primase small subunit PriS (Gene Name=priS)